Exhibit A 3713:
The near side is smooth on the circumference, but the far side has a wavy pattern. In Lego directions, the photos usually show the "orientation" of the bushing, but if I put it on the incorrect way, will it affect the build?
The answer is studs. Note that there are more pieces with the same ability.
Orientation of the bushing does matter when you run a rotating axle through a technic plate. Have the round side of the bushing pointing towards the studs. Otherwise the axle might lock up.
Here's an example from set 852 where this technique is used to attach the helicopter's rotor and propeller to an axle.
The wavy side allows you to wedge the bush between 4 studs on a plate or brick.
In my experience, placing the bush differently orientated never affects the build.